MAKE Wellness
06 February 2026
In this opening episode of our two-part series, Dr. Mark Bartlett and Dr. Alan Jones introduce the fundamental science behind GLP-1 receptor agonists, moving beyond the headlines to explore how these therapies actually function within the body. We weigh the significant metabolic benefits against potential drawbacks, providing a balanced look at the pros and cons of synthetic therapy. A central focus is the concept of "half-life"—understanding how long these molecules remain active in your system and why that timing is critical for managing both results and the biological "rebound" effect. We dive into the efficacy of naturally occurring peptides and how supporting your body’s endogenous production can, for many, be a more sustainable and effective route than clinical alternatives. "The information discussed on this podcast is for educational and informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast."
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