Science Friday and WNYC Studios
02 October 2025
Roughly 1 in 10 Americans take antidepressants. The most common type is SSRIs, or selective serotonin re-uptake inhibitors, like Prozac, Lexapro, and Zoloft. But what happens when you stop taking them? Studies don’t point to a single conclusion, and there’s ongoing debate among physicians and patients about the severity and significance of SSRI withdrawal symptoms. The discourse reached a fever pitch when Health Secretary Robert F. Kennedy Jr. compared SSRI withdrawal to heroin withdrawal in January. Host Flora Lichtman digs into the data on SSRI withdrawal with psychiatrists Awais Aftab and Mark Horowitz. Guests: Dr. Awais Aftab is a clinical associate professor of psychiatry at Case Western Reserve University. Dr. Mark Horowitz is a clinical research fellow in the UK’s National Health Service and scientific co-founder of Outro Health. Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Follow our show on Instagram, TikTok, Facebook, and Bluesky @scifri and sign up for our newsletters. Got a science question that’s keeping you up at night? Call us: 877-4-SCIFRI Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
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