Episode (200)
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The Death of Search: How Shopping Will Work In The Age of AI
Sep 17, 2025The web is unhealthy, and AI agents are about to rewrite how we shop. In this episode, a16z General Partner Alex Rampell and Partner Justine Moore explore how AI agents will change commerce and the im...
How OpenAI Built Its Coding Agent
Sep 16, 2025OpenAI’s Codex has already shipped hundreds of thousands of pull requests in its first month. But what is it really, and how will coding agents change the future of software? In this episode, General ...
Faster Science, Better Drugs
Sep 15, 2025Can we make science as fast as software? In this episode, Erik Torenberg talks with Patrick Hsu (cofounder of Arc Institute) and a16z general partner Jorge Conde about Arc’s “virtual cells” moonshot,...
Ben Horowitz: Why Hesitation is a CEO’s Worst Enemy
Sep 12, 2025In this conversation from Lenny’s Podcast, Ben Horowitz joins Lenny to discuss the psychological muscle every founder needs, why hesitation can be fatal for CEOs, when it’s time to replace a founder, ...
Inside the $13T Mortgage Machine
Sep 11, 2025The $13T U.S. mortgage market serves 50M homeowners but still runs on decades-old software. In this episode, a16z GP Angela Strange hosts Tim Mayopoulos (ex-CEO of Fannie Mae and ex-president of Blen...
Chris Dixon on How to Build Networks, Movements, and AI-Native Products
Sep 10, 2025Why do some consumer products explode into networks that reshape the internet, while others fade away? Today on the podcast, a16z general partners Anish Acharya and Chris Dixon take on that question. ...
Mark Cuban on the NBA, Cost Plus Drugs, and How to Fix Politics
Sep 09, 2025What happens when AI collides with salesmanship, streaming-era sports, and healthcare? In this episode, Erik Torenberg is joined by Mark Cuban, entrepreneur, Dallas Mavericks co-owner, and founder of ...
The Little Tech Agenda for AI
Sep 08, 2025Who’s speaking up for startups in Washington, D.C.? In this episode, Matt Perault (Head of AI Policy, a16z) and Collin McCune (Head of Government Affairs, a16z) unpack the “Little Tech Agenda” for AI-...
Building APIs for Developers and AI Agents
Sep 06, 2025Stainless founder Alex Rattray joins a16z partner Jennifer Li to talk about the future of APIs, SDKs, and the rise of MCP (Model Context Protocol). Drawing on his experience at Stripe—where he helped ...
How to Be Free: Shaka Senghor, Oprah Winfrey, Ben Horowitz
Sep 05, 2025Taken from The Oprah Podcast, this special episode brings together Shaka Senghor, a16z cofounder Ben Horowitz, and Oprah Winfrey for a powerful conversation on resilience and transformation. Shaka, a ...