Episode (156)
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AI for Atoms: How Periodic Labs is Revolutionizing Materials Engineering with Co-Founder Liam Fedus
Apr 03, 2026What happens when you apply the scaling laws of large language models to the physical work of atoms? Elad Gil sits down with Liam Fedus, co-founder at Periodic Labs, which is pioneering an AI foundati...
Andrej Karpathy on Code Agents, AutoResearch, and the Loopy Era of AI
Mar 20, 2026What happens when AI agents can design experiments, collect data, and improve — without a human in the loop? Andrej Karpathy joins Sarah Guo on the state of models, the future of engineering and educa...
From Coder to Manager: Navigating the Shift to Agentic Engineering with Notion Co-Founder Simon Last
Mar 12, 2026Notion isn’t designing AI agents that just use tools. Their agents can autonomously build their own integrations, as well as write the code needed to finish a task. Sarah Guo sits down with Notion Co-...
How Capital is Powering the AI Infrastructure Buildout with Magnetar Capital Managing Director Neil Tiwari
Feb 26, 2026By the end of 2026, AI capital expenditure is projected to hit nearly $700 billion. The question isn’t who has the best model, but who has the most creative financing to build out AI infrastructure an...
From SaaS to AI-First: How Companies Are Reshaping Innovation
Feb 19, 2026In this episode of No Priors, Sarah and Elad dive into the evolving landscape of software, exploring how AI is transforming the traditional SaaS model. They discuss whether SaaS as we know it is comin...
Rivian’s Roadmap to AI Architecture and Autonomy with Founder and CEO RJ Scaringe
Feb 12, 2026Autonomous vehicle technology has moved past human-coded rules and into an era of neural networks and custom computer chips. And to solve the most difficult driving scenarios, electric vehicle company...
Introducing 4D Creation Open Beta: NPCs, 4D Worlds, and the Future of Gaming with Roblox CEO Dave Baszucki
Feb 05, 2026From “virtual doppelgängers” to “real-time dreaming,” online gaming platform Roblox is using AI technology to build the “Holodeck” envisioned in science fiction decades ago. Sarah Guo and Elad Gil sit...
Why Cryopreservation is No Longer Science Fiction with Until Co-founder and CEO Laura Deming
Jan 29, 2026What if we could pause biological time to wait for a cure for a disease? Thanks to innovations and research in reversible cryopreservation, this possibility is no longer just science fiction. Sarah Gu...
No Priors Live: Building Durable Software in the AI Age with MongoDB President & CEO CJ Desai
Jan 22, 2026Why are there only a handful of companies in the world with over $10 billion in pure-play software revenue? CJ Desai believes the reason is that products are replaceable, but platforms are forever. Fo...
AI and the Future of Warfare with US Under Secretary of War Emil Michael
Jan 15, 2026Today’s arms race looks a little different from those of the past. Under the Trump administration, the US Department of War (DoW) is deploying generative AI to millions of employees in order to mainta...