Y Combinator Startup Podcast

Y Combinator Startup Podcast

Y Combinator

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Episode (200)

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1
How The Best Companies Defend Against Mediocrity And Rot

How The Best Companies Defend Against Mediocrity And Rot

May 25, 2026

In this episode of the Main Function Garry sits down with Eric Ries, author of "The Lean Startup", about his new book, "Incorruptible: Why Good Companies Go Bad And How Great Companies Stay Great". Ri...

2
Paul Graham: Should you move to Silicon Valley?

Paul Graham: Should you move to Silicon Valley?

May 13, 2026

Paul Graham is a co-founder of Y Combinator. He's funded and mentored companies like Dropbox, Airbnb, DoorDash, and thousands of others through YC, and is one of the most influential voices in the sta...

3
Tokenmaxxing: How Top Builders Use AI To Do The Work Of 400 Engineers

Tokenmaxxing: How Top Builders Use AI To Do The Work Of 400 Engineers

May 08, 2026

We're entering a new era of software where a single person, working with AI agents, can build products that previously required entire teams.In this episode of Lightcone, the hosts break down the rise...

4
Beyond Bigger Models: Recursion As The Next Scaling Law In AI

Beyond Bigger Models: Recursion As The Next Scaling Law In AI

May 01, 2026

A 7-million parameter model outperforming models a thousand times its size on tasks like ARC Prize. That's what recursive reasoning unlocks.In this episode of Decoded, YC's Ankit Gupta and Francois Ch...

5
How to Build the Future: Demis Hassabis

How to Build the Future: Demis Hassabis

Apr 29, 2026

Demis Hassabis has had one of the most extraordinary careers in tech. He started as a chess prodigy and video game designer at 17 before getting a PhD in neuroscience and going on to found DeepMind. H...

6
The $9B Startup That Wants to Create a Billion New Developers

The $9B Startup That Wants to Create a Billion New Developers

Apr 25, 2026

Replit is the leading no-code app builder for consumers and enterprise, letting anyone with an idea build real, deployed software using natural language. The company just raised a $400 million Series ...

7
The Playbook For Building An AI Native Company

The Playbook For Building An AI Native Company

Apr 24, 2026

AI isn't just making teams more productive. It's changing how companies should be built. In this episode of Startup School, YC Partner Diana Hu explains what it means to build an AI-native company, wh...

8
Stripe Head of Design Katie Dill Breaks Down Their New Website

Stripe Head of Design Katie Dill Breaks Down Their New Website

Apr 22, 2026

Even the most successful websites eventually need a redesign. Take Stripe for example. After six years with the same homepage, they recently unveiled a brand new site that reflects how the fintech gia...

9
The GPT Moment for Robotics Is Here

The GPT Moment for Robotics Is Here

Apr 16, 2026

Physical Intelligence is building a foundation model that can control any robot to do any task — what the team describes as the GPT-1 moment for robotics. The company's cross-embodiment approach train...

10
This Startup Wants To Catch Cancer Before It Spreads

This Startup Wants To Catch Cancer Before It Spreads

Apr 06, 2026

1 in 11 babies born in America this year will be screened by a genetic test that didn't exist a decade ago.Biotech startup BillionToOne turned a simple but radical idea—detecting rare fragments of fet...

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